Research projects
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Characterisation of therapeutic anti-CXCR4 antibodies
In this project, therapeutic antibodies against CXCR4 are characterised, which have been selected from large scFv phage libraries and engineered into complete human(ised) antibodies in collaboration with ModiQuest BV.
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Are glycans crucial determinants of autoantibody reactivity in multiple sclerosis?
In this pilot project the role of glycosylation in the autoantibody response in MS will be unexplored.
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Functional characterisation of the human sialyltransferase isoenzyme family
The project aims to decipher the specific functions of individual STfs isoenzymes to elucidate their biological roles which could warrant further investigation into their roles in diseases as inflammation where glycosylation changes are described.
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Genetic and chemical engineering of sialoglycoproteins in human cells
This project is focused on the use genetic engineering and chemically-modified sugar building blocks to dissect the biosynthetic network of glycosyltransferases.
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Epithelial glycosylation in the human colon and cross-talk with the microbiome
Glycosylation will be studied in vitro with 2D and 3D models, and by using techniques like omics and CRISPR-Cas. This will be done in healthy and diseased settings.
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The molecular basis of the accumulation of cytosolic 5’-nucleotidase 1A in inclusion body myositis
In this project we focus on anti-cN1A response in IBM patients and intracellular accumulation of cN1A. By characterizing tanti-cN1A autoantibodies produced by IBM patients we want to elucidate role of these antibodies in pathogenesis of this disease
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Agglutination assay for rheumatoid arthritis biomarkers
The project aims to make early testing more accessible, both for screening at primary care providers and in countries around the world lacking the infrastructure for more advanced tests.
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Towards a comprehensive understanding of the biochemical function of the human RNase MRP
Precursor of ribosomal RNA, cyclin B2 mRNA and viperin mRNA have been identified as substrates, but evidence for cyclin B2 mRNA cleavage is ambiguous. The goal of the project is to characterize the biochemical function of the human RNase MRP complex.